منابع مشابه
Thymic lymphocytes in obese (ob-ob) mice. A mirror of the insulin receptor defect in liver and fat.
In the genetically obese (ob/ob) mouse, a well characterized model of insulin resistance, the number of insulin receptors on thymic lymphocytes is decreased as has been previously noted with liver cells and with liver and fat cell membranes from these animals. Furthermore, insulin stimulates the transport of cr-aminoisobutyric acid less effectively in thymocytes from the obese mice than in cell...
متن کاملThymic Lymphocytes in Obese (ob/ ob) Mice A MIRROR OF THE IKSULIN RECEPTOR DEFECT IN LIVER AND E’AT*
In the genetically obese (ob/ob) mouse, a well characterized model of insulin resistance, the number of insulin receptors on thymic lymphocytes is decreased as has been previously noted with liver cells and with liver and fat cell membranes from these animals. Furthermore, insulin stimulates the transport of cr-aminoisobutyric acid less effectively in thymocytes from the obese mice than in cell...
متن کاملMechanisms of chloride transport in thymic lymphocytes.
This study examined mechanisms of Cl- transport in rat lymphocytes under a variety of conditions. Basal intracellular Cl- concentration ([Cl-]i) was not different between cells assayed in the presence of HCO3- or its absence (HEPES). Removal of external Cl- resulted in a fall in [Cl-]i and a rapid rise in intracellular pH (pH(i)). Both Cl- efflux and the rise in pH(i) were blocked by DIDS or re...
متن کاملIonizing radiation induces ferroptosis in splenic lymphocytes of mice
Backgrounds: It remains unclear whether radiation-induced haemorrhage in the spleen causes iron accumulation, and subsequently, ferroptosis in splenic lymphocytes. In this study, we investigated the occurrence of ferroptosis in splenic lymphocytes of gamma-irradiated mice. Materials and Methods: Mice were subjected to gamma radiation from a 137Cs source. Iron, Ferroportin 1, and iron regulatory...
متن کاملThymic output in aged mice.
Using GFP to mark recent thymic emigrants (RTEs) in mice carrying a GFP transgene driven by the recombination-activating gene 2 promoter, we demonstrate that RTEs are readily detectable even in 2-year-old mice, despite the fact that the proportion of the peripheral T cell pool comprised of RTEs declines with age. Although the number of RTEs decreases after reaching a peak at 6 weeks of age, thy...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1974
ISSN: 0021-9258
DOI: 10.1016/s0021-9258(19)42492-7